I think this is possible. I was copying a new map to the bin file and it converted it from open loop to closed loop upon upload. Didn't notice it, took for test drive, went WOT, and noticed issues. Took it home and saw the issue.
Checked compression recently and I'm @ 90 psi on #2. Whether it was a result of the above or something else I'm not sure but I'd keep it in mind if you use tunerpro to recheck maps after uploading.